Advanced Cholesterol Testing


Overview of lipoprotein particles and cholesterol Cholesterol testing has historically been used as the standard indicator for cardiovascular disease classified as HDL (good) or LDL (bad). However, it is actually the lipoprotein particles that carry the cholesterol throughout the body, not necessarily the cholesterol within them, that are responsible for key steps in plaque production and the resulting development of cardiovascular disease.

Approximately 50 percent of people suffering from heart attacks have shown“normal” cholesterol numbers (NIH – National Heart Blood and Lung Institute). Now there is an advanced cholesterol testing technology which accurately measures both the density and number of lipoprotein particles. This test is the Lipoprotein Particle Profile™, or LPP™, from SpectraCell Laboratories. Measuring the lipoprotein subgroups is the only way to evaluate new risk factors, which is crucial for an accurate assessment of cardiovascular risk – according to the National Cholesterol Education Program (NCEP).

NCEP new Risk Factors:

  • Small, dense LDL: these atherogenic particles are easily oxidized and penetrate the arterial endothelium to form plaqu
  • Lp(a): this small, dense LDL is involved in thrombosis RLP (Remnant Lipoprotein): is very atherogenic, has a similar composition and density of plaque, is believed to be a building block of plaque and does not need to be oxidized like other LDL particle
  • HDL2b: positively correlates with heart health because it is an indicator of how well excess lipids are removed

Why is it important to know lipoprotein numbers? Cardiovascular risk increases with a higher LDL particle count. With a higher non-HDL lipoprotein count the probability of particle penetration of the arterial wall rises, regardless of the total amount of cholesterol contained in each particle. On average, the typical particle contains 50 percent cholesterol. More than 20 percent of the population has cholesterol-depleted LDL, a condition in which a patient’s cholesterol may be “normal” but their lipoprotein particle number, and hence their actual risk, could be much higher than expected. This is especially common in persons whose triglycerides are high or HDL is low. In the population with a cholesterol-depleted LDL, there can be up to a 40 percent error in risk assessment.

Lipoprotein Particle Profile™ (LPP™) Providing a Complete Look at Lipoprotein Subgroups SpectraCell’s LPP™ test is a proprietary technology originally developed at Texas A&M University that separates the lipoproteins in blood serum by density using analytical ultracentrifugation, the CDC gold standard for lipoprotein testing, then measures the particles photometrically.

Use LPP™ in your practice for accurate a therogenic risk assessments Traditionally, the standard lipid panel calculates LDL from measurements of the other lipoproteins. In contrast, the LPP™ method presents values for all of the lipoproteins from direct measurement. SpectraCell’s LPP™ technology aids the physician in assessing a patient’s cardiovascular risk. With LPP™, a physician can begin to treat patients with atherogenic lipoprotein profiles before overt dyslipidemia becomes apparent.

Dr. Afshine Emrani is a cardiologist who serves the residents of Tarzana, California, in addition to the greater Los Angeles area. At Los Angeles Heart Specialists, the doctor and his staff offer a variety of cardiology services including preventative care for heart disease, stress testing, treadmill testing, and treatment of many different kinds of health conditions including high blood pressure, high cholesterol, diabetes, thyroid disorders, and peripheral arterial disease. Dr. Emrani specializes in identifying biomarkers and other naturally occurring identifiers that help him treat heart disease in both men and women. He offers a wide variety of services to his patients including weight management plans, the control and maintenance of cholesterol levels, and nutritional plans geared towards a more heart-healthy lifestyle. An on-site lab makes testing quick and cost-effective.

Dr. Emrani attended the University of California, Los Angeles where he obtained his Bachelor of Science degree where he was inducted into the Biological Honors Society. He also attended the University of California, San Diego where he completed his medical degree. During that time, he participated in two sub-internships, one in Cardiology and the other in Intensive Care. He also worked at the Cedar Sinai Medical Center and completed an additional sub-internship infectious disease. An internship was also completed during the years he worked with the Veteran's Affairs Administration. While working at the Kaiser Permanente campus of the University of Southern California, Dr. Emrani earned a fellowship in the field of Cardiology.

With over 16 years experience, Dr. Emrani is a leader in his field. His knowledge of cutting-edge technology and the use of state-of-the-art diagnostic equipment allows him the privilege of offering his patients the best cardiac care possible. He continues his education on a regular basis by attending classes and seminars that allow him to stay abreast of the latest advancements in the field of cardiology and infectious diseases. His certification in both basic and advanced cardiac life support makes him one of the most prominent cardiologists in Southern California.

About LA Heart Specialists

At Los Angeles Heart Specialists with our integrative heart doctors, you will learn more about your health in one visit than you ever thought possible. Our comprehensive health evaluation enables you to make health and lifestyle decisions that will support your long-term wellness.

Through preventive care and early diagnosis, we can help you address any undetected health issues—and give you the peace of mind that can only come with a thorough picture of your health. Your introductory visit will require the most in-depth health exam, to establish your complete health status and individual profile. Subsequent visits with us will include only those tests appropriate to your personal medical history—to ensure your optimal long-term health and well-being.

We take pride in offering “concierge medicine” without the extra costs. Most urgent calls can be triaged and patients seen in a very timely manner. Whenever possible, we avoid invasive procedures as well as hospitalization. In fact, for the large volume of patients seen in our practice, we rarely admit to the hospital. This is the result of hard work and aggressive preventive measures that are oriented to keeping our patients healthy and independently functional.

Our Integrative Approach

• Customized Treatments Just for You

• Pharmaceutical and Nutraceutical Therapies

• Comprehensive Lab Testing 

Superior Care

• Comprehensive Health Evaluation

• Electronic Medical Records

• "Concierge Medicine" Without the Extra Costs

Healthy Patients

• 99% Patient Satisfaction Rate

• Industry-leading Customer Service

• Rated Top %5 Physicians in America

Visiting Hours

Walk-in consultations are available at the following times:

MON, TUE and THU: 8:30 AM - 5:00 PM
WED and FRI: 8:30 AM - 4:00 PM

All other times by appointment only.


The L.A.H.S. Executive Physical

If you are a CEO, CFO, or a very busy executive, then it is challenging for you to get your annual physical. At your convenience, LA Heart Specialists can provide you the full range of services on a cash basis - on Saturday or Sunday of your choice. The services include - the executive physical, comprehensive laboratory testing, lipid and nutritional analysis, pulmonary function testing, allergy testing, bone densitometry and a comprehensive cardiovascular stress test.

Your time is valuable. But so is your health. That’s why The L.A.H.S Executive Physical offers an efficiently organized and comprehensive set of examinations in just one day. Your health status will be thoroughly evaluated to determine a preventive health care program tailored to your individual needs.

This package is $2600 (less than a dental implant.)

Call now to schedule your Executive Physical. 818-996-4100.

Services include:

  • A thorough, extended physical examination with an internal medicine specialist whose focus is on disease prevention and/or women’s health
  • Comprehensive laboratory testing, including blood counts, chemistry panels to assess organ function, urinalysis, and cholesterol screening
  • Cardiovascular assessment, including electrocardiogram (ECG) and one or more of the following based on your doctors recommendations: cardiac stress echocardiogram, resting echocardiography, or advanced cardiovascular blood tests with carotid intima-medial thickness scanning, and Doppler flow peripheral vascular index testing
  • Pulmonary function testing
  • A comprehensive written report of the evaluation sent to your home (and your physician, upon request) Women’s health concerns
  • Osteoporosis testing (women over 40 years of age)
  • Prostate examination/Prostate Specific Antigen (PSA/free PSA) Screening
  • Referral for screening colonoscopy, mamography etc will be made as necessary.

The L.A.H.S. Check-Up

Busy executives, who face ever-increasing demands on their time, often find it difficult to take care of their health as conscientiously as they know they should. While it is well known that early detection of medical problems leads to better health outcomes, practicing good, preventive medicine can be a challenge when it means having to schedule multiple diagnostic exams and consultations.

University Executive Physical Program was designed to offer executives comprehensive examinations with a full battery of diagnostic tests scheduled in a single, coordinated visit. Our patients enjoy a level of service and convenience not available in most other programs because we own the equipment used for most diagnostic tests — there’s no need to waste time waiting in other medical offices for these services.

The University Executive Physical Program offers:

▪ Comprehensive examinations customized to the executive’s need
▪ Personal one-on-one attention from the physician
▪ Diagnostic tests performed right in the executive suite
▪ Convenient Westside location with easy access
▪ State-of-the-art technology
▪ Centralized billing

Live a healthy life: With our preventive medical checkups, we can help detect illness early on and treat it accordingly.

We offer the following preventive medical checkups:

▪ Routine health checkup
▪ Cancer prevention
▪ Cardiovascular
▪ Thyroid, arteries and heart
▪ Examination of metabolism and digestion
▪ Physical examination

Your health insurance policy may cover the cost of preventive medical checkups. Consult your insurance provider for further details.

Major Insurance Plans Accepted

We accept most major insurance plans | If you have any questions, please call our office | We are out of network for United Health Care | We do not accept Blue Shield

Our Team

We are here to help

  • Nolynne  Rodriguez
    Nolynne Rodriguez
    Certified Physician Coder
  • Susan  Khalily
    Susan Khalily
    Chief Laboratory Technician
  • Sean  Jabari
    Sean Jabari
    X-Ray Technologist, Bone Densitometry
  • Rita Amaro Wisotsky
    Rita Wisotsky
  • Tatyana  Slyusaranskaya
    Tatyana Slyusaranskaya
  • Jeffrey  Eskew
    Jeffrey Eskew
    Laboratory Technical Supervisor
  • Claudia  Brown
    Claudia Brown
    Onsite Office Manager


Los Angeles Heart Specialists
18370 Burbank Blvd., Suite 401
Tarzana, CA 91356
Phone: 818-996-4100
Fax: 818-996-0842

Office Hours

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