#Advil vs. #Tylenol. Tylenol is a brand of acetaminophen and Advil is a brand of ibuprofen. Tylenol is only effective at relieving pain and fever, but Advil relieves inflammation in addition to pain and fever. Some research suggests NSAIDs (such as Advil, Motrin, Naprosyn) are more effective than Tylenol at relieving pain. Too much Tylenol can cause liver damage. Too much NSAIDs can cause stomach ulcers and kidney failure as well as high blood pressure. You should check with your doctor which is the best option for you, given your medical condition, and how much you can take in one day.